Institude of Integrated Mircosystems Funded Project
Project Title:
An Integrated PCR-Electtochemical Microdevice for Simultaneous DNA Amplification
and Detection
Principal Investigator:
Prof I-Ming Hsing,
Department of Chemical Engineering, HKUST.
Project Duration:
30 months(July 1, 2002 to Dec. 31, 2004)
Project Summary:
In this project, we developed and characterized an integrated microdevice for
simultaneous deoxyribonucleic acid (DNA) amplification and detection.
The realization of such miniaturized device would be of great practical value for
point-of-care genetic analysis.
Research Output:
- Publication
- H. Cai, C. Shang and I-M. Hsing, ¡§Sequence-Specific
Electrochemical Recognition of Multiple Species using Nanoparticle Labels,¡¨
Analytica Chimica Acta, 523(1) 61-68 (2004)
- T. H. M. Lee, M. Carles and I.M. Hsing, ¡§Microfabricated
PCR-Electrochemical Device for Simultaneous DNA Amplification and Detection¡¨,
Lab on a Chip, 2 (2003)
- T. H. M, Lee, Lulu Li and I-M. Hsing, ¡§Enhanced
Electrochemical Detection of DNA Hybridization Based on Electrode Surface
Modification,¡¨ Langmuir, 19(2003) 4339-4343
- T. M. H. Lee and I-M Hsing, ¡§Sequence-Specific
Electrochemical Detection of Asymmetric PCR Amplicons of Tradition Chinese
Medicinal Plant DNA¡¨, Analytical Chemistry, 74(2002) 5057-5062
- Student trained
- Thomas M. H. Lee, Ph.D Chemical Engineering, May 2003. Thesis Title: Sequence-Specific
electrochemical DNA Detection and Its Implementation in Integrated PCR-electrochemical
Microdevices
- Lulu Li, Mphil. |BioEngineering, July 2004, Thesis Title: Ag/Au Nanpparticle-based
Electrochemical Detection of DN: Its Application in Bioaerosols Recognition
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